Background:
@EN Antimuscarinic agents are used to block undesirable muscarinic effects of anticholinesterase given to reverse the residual neuromuscular blockade produced by muscle relaxants. However, besides antimuscarinic effects, atropine was known to
have
some
positive effects on the recovery from neuromuscular blockade by acting at the presynaptic muscarinic receptor of the neuromuscular junction. But there have been few reports about the neuromuscular effects of glycopyrrolate. So we observed the
neuromuscular effects of atropine and glycopyrrolate, and compared two.
@ES Methods:
@EN Mivacurium(0.064 mg/kg) was administered intravenously and the experimental groups were divided into 5 groups: the control group (no antimuscarinic agent administered), A1 groups (0.02 mg/kg atropine administered), A2 group(0.04 mg/kg
atropine
administered), G1 group (0.01 mg/kg glycopyrrolate administered) and G2 group (0.02 mg/kg glycopyrrolate administered). The left common peroneal nerve was stimulated by the 0.1 Hz single twitch and 100Hz tetanic stimuli. We monitored the
mechanical
activity of the anterior tibialis muscle and observed recovery index, tetanic fade, and post-tetanic potentiation.
@ES Results:
@EN There were no significant differences in recovery indices and post-tetanic potentiations among the 5 groups. Significant differences were found in tetanic fades between the experimental groups (A1, A2, G1, G2) and the control group(P<0.05).
However
no significant differences in tetanic fades were found among the experimental groups.
@ES Conclusions:
@EN Atropine and glycopyrrolate hastened the recovery from mivacurium induced neuromuscular blockade. The neuromuscular recovery effects of glycopyrrolate were found to be similar to atropine at equipotent dose.(Korean J Anesthesiol 1996; 30:
419~425)
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